منابع مشابه
[Prostaglandins and leukotrienes].
Two classes of arachidonic acid derivatives can be formed by two distinct enzyme systems. Cyclo-oxygenases synthesise prostaglandins, prostacyclin and thromboxane A2 which all possess both pro- and anti-inflammatory properties. Lipoxygenases synthesise on the one hand chemotactic factors, the hydroxylated derivatives of arachidonic acid, the most powerful of which is leukotriene B4, and on the ...
متن کاملProstaglandins Leukotrienes and Essential Fatty Acids
The incorporation of (n-3) versus (n-6) fatty acids into membrane lipids is regulated by a number of different processes within the cell. It is generally accepted that a common 6-desaturase uses both linoleate and linolenate as substrates. Desaturation of linoleate and linolenate are generally considered to be the rate limiting steps in the biosynthesis of arachidonate and 20:5(n-3) respectivel...
متن کاملProstaglandins, Leukotrienes, and the Immune Response
disease in a patient who looks well, by aggressive treatment of mild or moderate attacks and by the standardization of a protocol for the management of these severe attacks." Of topical interest is the chapter on the role of the gastroenterologist with the HIV-infected patient. The author examines the responsibilities of the physician for managing the multiple clinical presentations, ranging fr...
متن کاملProstaglandins, Leukotrienes and Essential Fatty Acids
Eicosapentaenoic acid (EPA) is a member of the family of n-3 polyunsaturated fatty acids (PUFAs) that are clinically used to treat hypertriglyceridemia. The triglyceride (TG) lowering effect is likely due to an alteration in lipid metabolism in the liver, but details have not been fully elucidated. To assess the effects of EPA on hepatic TG metabolism, mice were fed a high-fat and high-sucrose ...
متن کاملProstaglandins and leukotrienes: advances in eicosanoid biology.
Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that are involved in numerous homeostatic biological functions and inflammation. They are generated by cyclooxygenase isozymes and 5-lipoxygenase, respectively, and their biosynthesis and actions are blocked by clinically relevant nonsteroidal anti-inflammatory drugs, the n...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1985
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.60.6.597-b